POLYAMIDE
A polyamide
is a polymer containing monomers of amides joined by peptide bonds. They can occur both naturally and artificially,
examples being proteins, such as wool and silk,
and can be made artificially through step-growth polymerization
or solid-phase synthesis,
examples being nylons, aramids, and sodium poly(aspartate).
Polyamides are commonly used in textiles, automotives, carpet and sportswear
due to their extreme durability and strength.
Classification
According to the composition of
their main chain, polyamides are classified as follows:
Polyamide
family
|
Main
chain
|
Examples
of polyamides
|
Examples
of commercial products
|
Aliphatic
polyamides
|
Aliphatic
|
||
Semi-aromatic
|
PA
6T = hexamethylenediamine + terephthalic acid
|
||
Aramides = aromatic polyamides
|
Aromatic
|
Paraphenylenediamine +
terephthalic acid
|
According to the number of repeating
units' types, polyamides can be:
- homopolymers :
- PA 6 : [NH−(CH2)5−CO]n made from ε-Caprolactam ;
- PA 66 : [NH−(CH2)6−NH−CO−(CH2)4−CO]n made from hexamethylenediamine and adipic acid;
- copolymers :
- PA 6/66 : [NH-(CH2)6−NH−CO−(CH2)4−CO]n−[NH−(CH2)5−CO]m made from caprolactam, hexamethylenediamine and adipic acid ;
- PA 66/610 : [NH−(CH2)6−NH−CO−(CH2)4−CO]n−[NH−(CH2)6−NH−CO−(CH2)8−CO]m made from hexamethylenediamine, adipic acid and sebacic acid.
According
to their crystallinity, polyamides can be:
- semi-crystalline:
- high crystallinity : PA46 et PA 66 ;
- low crystallinity : PA mXD6 made from m-xylylenediamine and adipic acid;
- amorphous : PA 6I made from hexamethylenediamine and isophthalic acid.
According
to this classification, PA66, for example, is an aliphatic semi-crystalline
homopolyamide.
Production from monomers
The
amide link is produced from the condensation reaction of
an amino group and a carboxylic acid or acid chloride group. A small molecule, usually water,
or hydrogen chloride, is
eliminated.
The
amino group and the carboxylic acid group can be on the same monomer, or the
polymer can be constituted of two different bifunctional monomers, one with two amino groups, the other
with two carboxylic acid or acid chloride groups.
Amino acids can be taken as examples of single monomer (if the
difference between R groups is ignored) reacting with identical molecules to form
a polyamid
The
reaction of two amino acids. Many of these reactions produce long chain proteins
Aramid
(pictured below) is made from two different monomers which continuously
alternate to form the polymer and is an aromatic polyamide:
The
reaction of 1,4-phenyl-diamine (para-phenylenediamine) and terephthaloyl
chloride to produce Aramid
β-LACTAM ANTIBIOTIC
β-Lactam antibiotics (beta-lactam antibiotics) are
a broad class of antibiotics, consisting of all antibiotic
agents that contains a β-lactam nucleus in their molecular structures.
This includes penicillin derivatives (penams),
cephalosporins (cephems), monobactams, and carbapenems. Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the
most widely used group of antibiotics. Up until 2003, when measured by sales,
more than half of all commercially available antibiotics in use were β-lactam
compounds.
Bacteria often develop
resistance to β-lactam antibiotics by synthesizing a β-lactamase, an enzyme that attacks the β-lactam ring. To
overcome this resistance, β-lactam antibiotics are often given with β-lactamase inhibitors
such as clavulanic acid.